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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PLK4
All Species:
13.03
Human Site:
Y650
Identified Species:
28.67
UniProt:
O00444
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O00444
NP_055079.3
970
108972
Y650
G
N
T
I
T
I
Y
Y
P
N
G
G
R
G
F
Chimpanzee
Pan troglodytes
XP_517431
973
109258
Y650
G
N
T
I
T
I
Y
Y
P
N
G
G
R
G
F
Rhesus Macaque
Macaca mulatta
XP_001105577
970
108780
Y650
G
N
M
I
T
I
Y
Y
P
N
D
G
R
G
F
Dog
Lupus familis
XP_533295
969
109039
Y649
G
N
M
I
T
I
Y
Y
P
N
D
G
R
G
F
Cat
Felis silvestris
Mouse
Mus musculus
Q64702
925
103728
M606
Q
I
S
S
D
G
T
M
I
T
V
Y
Y
P
N
Rat
Rattus norvegicus
B2GUY1
924
103752
I606
I
S
S
D
G
T
T
I
T
V
Y
Y
P
N
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516165
519
56295
G201
A
E
A
R
D
L
I
G
R
L
L
R
R
D
P
Chicken
Gallus gallus
Frog
Xenopus laevis
Q6PAD2
944
105622
Y626
S
C
D
G
N
L
I
Y
V
Y
H
P
N
E
G
Zebra Danio
Brachydanio rerio
Q7ZVS3
940
103466
M622
R
I
S
C
D
G
S
M
V
T
V
Y
Q
P
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O97143
769
85869
G451
I
I
Y
Q
P
D
P
G
R
G
L
P
V
R
E
Honey Bee
Apis mellifera
XP_623133
730
82506
K412
R
L
Q
P
T
R
H
K
T
K
Y
T
I
L
T
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.8
97.3
88.7
N.A.
78.8
78.9
N.A.
30.6
N.A.
60.3
52.1
N.A.
28.9
35
N.A.
N.A.
Protein Similarity:
100
99.3
98.8
93.7
N.A.
86.9
86.5
N.A.
40.4
N.A.
74.1
67.1
N.A.
45.2
50.7
N.A.
N.A.
P-Site Identity:
100
100
86.6
86.6
N.A.
0
0
N.A.
6.6
N.A.
6.6
0
N.A.
0
6.6
N.A.
N.A.
P-Site Similarity:
100
100
86.6
86.6
N.A.
6.6
13.3
N.A.
13.3
N.A.
13.3
13.3
N.A.
0
13.3
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
10
0
10
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
10
10
28
10
0
0
0
0
19
0
0
10
10
% D
% Glu:
0
10
0
0
0
0
0
0
0
0
0
0
0
10
10
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
37
% F
% Gly:
37
0
0
10
10
19
0
19
0
10
19
37
0
37
10
% G
% His:
0
0
0
0
0
0
10
0
0
0
10
0
0
0
0
% H
% Ile:
19
28
0
37
0
37
19
10
10
0
0
0
10
0
0
% I
% Lys:
0
0
0
0
0
0
0
10
0
10
0
0
0
0
0
% K
% Leu:
0
10
0
0
0
19
0
0
0
10
19
0
0
10
0
% L
% Met:
0
0
19
0
0
0
0
19
0
0
0
0
0
0
0
% M
% Asn:
0
37
0
0
10
0
0
0
0
37
0
0
10
10
19
% N
% Pro:
0
0
0
10
10
0
10
0
37
0
0
19
10
19
10
% P
% Gln:
10
0
10
10
0
0
0
0
0
0
0
0
10
0
0
% Q
% Arg:
19
0
0
10
0
10
0
0
19
0
0
10
46
10
0
% R
% Ser:
10
10
28
10
0
0
10
0
0
0
0
0
0
0
0
% S
% Thr:
0
0
19
0
46
10
19
0
19
19
0
10
0
0
10
% T
% Val:
0
0
0
0
0
0
0
0
19
10
19
0
10
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
10
0
0
0
37
46
0
10
19
28
10
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _